发明名称 |
TARGETED GENE DELIVERY TO NON-PHAGOCYTIC MAMMALIAN CELLS VIA BACTERIALLY DERIVED INTACT MINICELLS |
摘要 |
<p>A method of targeting bacterially-derived, intact minicells to specific, non-phagocytic mammalian cells employs bispecific ligands to deliver nucleic acids efficiently to the mammalian cells. Bispecific ligands, comprising (i) a first arm that carries specificity for a bacterially-derived minicel surface structure and (ii) a second arm that carries specificity for a non-phagocytic mammalian cell surface receptor are useful for targeting minicells to specific, non-phagocytic mammalian cells and causing endocytosis of minicells by non-phagocytic cells.</p> |
申请公布号 |
EP1694361(B1) |
申请公布日期 |
2011.03.16 |
申请号 |
EP20040806560 |
申请日期 |
2004.12.08 |
申请人 |
ENGENEIC MOLECULAR DELIVERY PTY LTD. |
发明人 |
BRAHMBHATT, HIMANSHU;MACDIARMID, JENNIFER |
分类号 |
A61K48/00;C12N15/85;C12N15/88 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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