发明名称 |
Recombinant co-expression of vitamin K epoxide reductase subunit 1 to improve vitamin K dependant protein expression |
摘要 |
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems. |
申请公布号 |
EP2295547(A1) |
申请公布日期 |
2011.03.16 |
申请号 |
EP20100010933 |
申请日期 |
2006.01.27 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A. |
发明人 |
SCHEIFLINGER, FRIEDRICH;BOEHM, ERNST |
分类号 |
C12N9/04 |
主分类号 |
C12N9/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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