发明名称 |
Compare-MS: method rapid, sensitive and accurate detection of DNA methylation |
摘要 |
The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.
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申请公布号 |
US7906288(B2) |
申请公布日期 |
2011.03.15 |
申请号 |
US20070159081 |
申请日期 |
2007.01.04 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
NELSON WILLIAM G.;LIN XIAOHUI S.;DEMARZO ANGELO M.;NASUBRAMANIAN SRINIVASAN |
分类号 |
C12Q1/68;C07H21/02;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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