发明名称 Heterocyclic compounds as ccr2b antagonists
摘要 Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
申请公布号 US7906645(B2) 申请公布日期 2011.03.15
申请号 US20050793606 申请日期 2005.12.19
申请人 ASTRAZENECA AB 发明人 BOWER JUSTIN FAIRFIELD;POYSER JEFFREY PHILIP;WATERSON DAVID
分类号 C07D241/02;A61K31/495 主分类号 C07D241/02
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