BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS

摘要

The present invention is related to benzazole derivatives accord-ing to formula (I) wherein X is O, S, or NR O with R0 being H or an unsubstituted or substituted C1-C6alkyl, and G is an unsubstituted or substituted pyrimidinyl group, notably for use as pharmaceutically active compounds, as well as to phar-maceutical formulations containing such benzazoles derivatives. Said benzazoles derivatives are efficient modulators of the JNK pathway, they are in particular ef-ficient and selective inhibitors of JNK2 and/or 3.