发明名称 Menveo- oligosaccharide méningococcique du group A conjugué à la protéine CRM197 de Corynebacterium diphteriae.
摘要 Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide : MenC saccharide is >1.
申请公布号 LU91732(I2) 申请公布日期 2011.03.14
申请号 LU20100091732C 申请日期 2010.09.14
申请人 NOVARTIS AG. 发明人
分类号 A61K39/00;A61K39/02;A61K39/09;A61K39/095;A61K39/102;A61K39/39;A61P31/04;C08B37/00 主分类号 A61K39/00
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