TAXANE ANALOGUES, THEIR USE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION

摘要

The present invention relates to novel taxane analogues, processes of making the novel taxane analogues, compositions containing the novel taxane analogues, and their use in treating cancer and neurodegenerative disorders. In some embodiments, the taxane analogues are represented by the generic structure of formula (I) : wherein R1, R2,R3 and A are defined herein; and esters especially pro-drugs thereof wherein one or more of the hydroxy! groups is esterified to form an in-vivo hydrolysable ester group; or pharmaceutically acceptable salts thereof.