DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS
摘要
<p>Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therapeutic agent molecules into a cell. The therapeutic agents include both hydrophobic and hydrophilic. Different attachments of therapeutic agents in a composition are also described.</p>
申请公布号
WO2011028850(A1)
申请公布日期
2011.03.10
申请号
WO2010US47594
申请日期
2010.09.01
申请人
NORTHWESTERN UNIVERSITY;MIRKIN, CHAD, A.;GILJOHANN, DAVID, A.;DANIEL, WESTON, L.
发明人
MIRKIN, CHAD, A.;GILJOHANN, DAVID, A.;DANIEL, WESTON, L.