SYNTHETIC METHOD OF MONTELUKAST SODIUM INTERMEDIATE

摘要

A process for preparing montelukast sodium intermediate 2-(2-(3-(2-(7-chloro-2-quinolyl)ethenyl)phenyl-3-oxopropyl)phenyl) propanol is provided. In the process, the target compound is prepared by condensing the starting materials 7-chloroquinaldine and 3-cyanobenzaldehyde, and then reacting with 2-(2-ortho-(2-haloethyl)-phenylpropyl)tetrahydropyrane ether.