METHOD OF TREATING EXTRAABDOMINAL DESMOID TUMOURS

摘要

FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, oncology, and can be used for treatment of extraabdominal desmoids tumours. For this purpose tumour is influenced by teletherapy in daily mode and local electromagnetic hyperthermia in two stages. Teletherapy is carried out in form of small-fraction irradiation two times per day with 4 hour interval between fractions, SFD 1.2 Gy. At the 1 stage of irradiation Summary Focal Dose constitutes 41.6 Gy and all affected muscle and tendon are included into volume of irradiation. At the II stage Summary Focal Dose constitutes 23.6-26 Gy and volume of irradiation is successively reduced to the size of detected tumour and 2-3 cm of surrounding tumour tissues. Local electromagnetic hyperthermia is performed since the second day of irradiation immediately before the second daily fraction of irradiation 2 times a week with interval 72-96 hours. Treatment is carried out at the background of daily introduction of tamoxifen in dose 20 mg two times per day. ^ EFFECT: method makes it possible to improve treatment results due to increase of recurrence-free period, reduction of injuring action of radiotherapy on skin and soft tissues, reduce frequency and degree of expression of early and late radiation injury of healthy organs and tissues, entering irradiation zone. ^ 2 ex