发明名称 |
SUBSTITUTED HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF PAIN AND EPILEPSY |
摘要 |
<p>Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel activity, particularly unwanted Nav 1.7, Nav 1.8, or Cav 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine linked through an amide, isoxazole or similar linker to an aryl ring are described and are shown to be useful for the treatment of pain or epilepsy. A is selected from Formulae (i) or (ii).</p> |
申请公布号 |
WO2011026241(A1) |
申请公布日期 |
2011.03.10 |
申请号 |
WO2010CA01386 |
申请日期 |
2010.09.03 |
申请人 |
ZALICUS PHARMACEUTICALS LTD.;PAJOUHESH, HASSAN;GRIMWOOD, MIKE;ZHU, YONGBAO;DING, YANBING |
发明人 |
PAJOUHESH, HASSAN;GRIMWOOD, MIKE;ZHU, YONGBAO;DING, YANBING |
分类号 |
C07D241/08;A61K31/4462;A61K31/495;A61K31/496;A61P25/00;C07D211/34;C07D403/06;C07D413/06 |
主分类号 |
C07D241/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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