| 发明名称 |
COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY SELECTIVELY INHIBITING VEGF (VASCULAR ENDOTHELIAL GROWTH FACTOR) |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide new treatment compositions and methods for using the same in anti-angiogenesis and anti-tumor treatments. <P>SOLUTION: The new compositions are each provided by containing an anti-VEGF antibody or its antigen-bonding fragment of a biologically effective amount, and the antibody bonds with an epitope which is essentially the same as a monoclonal antibody ATCC PTA 1595, and significantly inhibits the bonding of the VEGF with a VEGF receptor VEGFR2(KDR/Flk-1), without significantly inhibiting the bonding of the VEGF with a VEGF receptor VEGFR1(Flt-1). <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
| 申请公布号 |
JP2011046720(A) |
申请公布日期 |
2011.03.10 |
| 申请号 |
JP20100223006 |
申请日期 |
2010.09.30 |
| 申请人 |
BOARD OF REGENTS THE UNIV OF TEXAS SYSTEM |
发明人 |
THORPE PHILIP E;BREKKEN ROLF A |
| 分类号 |
A61K39/395;C12N15/02;A01K67/027;A61K45/00;A61K47/48;A61K49/00;A61K49/04;A61K51/00;A61P1/04;A61P7/06;A61P7/10;A61P9/00;A61P9/10;A61P15/00;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/08;A61P27/02;A61P27/06;A61P27/10;A61P27/14;A61P29/00;A61P31/04;A61P31/18;A61P33/00;A61P33/02;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P43/00;C07K5/103;C07K14/52;C07K16/22;C07K16/24;C07K16/30;C12N5/02;C12N5/071;C12N5/10;C12N15/09;C12P21/08;G01N33/53 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
