METHODS AND COMPOSITIONS FOR INCREASING THE ACTIVITY OF INHIBITORY RNA
摘要
The invention provides methods for increasing the activity of an inhibitory RNA (RNAi) in a subject requiring administering one or more poly-ADP-ribose polymerase (PARP) inhibitors and/or one or more PARG activators to the subject. The invention also provides methods for increasing the activity of an inhibitory RNA in a cell or cell population requiring contacting a cell or cell population with one or more PARP inhibitors and/or one or more PARG activators. The invention further provides compositions and kits containing one or more PARP inhibitors and/or one or more PARG activators.
申请公布号
WO2010151773(A3)
申请公布日期
2011.03.10
申请号
WO2010US40002
申请日期
2010.06.25
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CHANG, PAUL;LEUNG, ANTHONY;SHARP, PHILLIP, A.