发明名称 |
GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES |
摘要 |
The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane. |
申请公布号 |
CA2772076(A1) |
申请公布日期 |
2011.03.10 |
申请号 |
CA20102772076 |
申请日期 |
2010.08.24 |
申请人 |
BAYLOR COLLEGE OF MEDICINE;WILSON WOLF MANUFACTURING CORPORATION |
发明人 |
LEEN, ANN MARIE;ROONEY, CLIONA;GERDEMANN, ULRIKE;VERA, JUAN |
分类号 |
C12N5/0783;A61K35/14;A61P37/02;C12N15/00 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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