摘要 |
The present disclosure encompasses type-I IFN and IFNa-induced PD marker expression profiles, kits, and methods for identifying such IFNa-induced PD marker expression profiles. The type-I IFN and IFNa-induced PD marker expression profiles may also be used in, for example, methods of treating patients having a type-I IFN or IFNa-mediated disorder, methods of monitoring disease progression of patients receiving treatment with a therapeutic agent that modulates type 1 interferon activity, identifying patients as candidates to receive a therapeutic that binds to and neutralizes IFNa activity, and in diagnosing or providing a prognosis to patients having IFNa-induced disorders. |
申请人 |
MEDIMMUNE, LLC;HIGGS, BRANDON;ZHU, WEI;MOREHOUSE, CHRIS;WHITE, BARBARA;JALLAL, BAHIJA;YAO, YIHONG |
发明人 |
HIGGS, BRANDON;ZHU, WEI;MOREHOUSE, CHRIS;WHITE, BARBARA;JALLAL, BAHIJA;YAO, YIHONG |