发明名称 |
P13k pathway mutations in cancer |
摘要 |
Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention.
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申请公布号 |
US2011059434(A1) |
申请公布日期 |
2011.03.10 |
申请号 |
US20060920860 |
申请日期 |
2006.05.23 |
申请人 |
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发明人 |
PARSONS DONALD WILLIAM;WANG TIAN-LI;SAMUELS YARDENA;BARDELLI ALBERTO;LENGAUER CHRISTOPHER;VELCULESCU VICTOR;KINZLER KENNETH W.;VOGELSTEIN BERT |
分类号 |
C12Q1/68;C12N9/12;C12Q1/48;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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