BENZOTRIAZINE COMPOUND AND APPLICATION THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a new compound that is low-invasive and exhibits excellent anti-brain tumor effects. SOLUTION: A benzotriazine compound represented by general formula (I) and a salt thereof are provided. In the formula, X1and X2are the same or different and are each N or an N-oxide group, provided that at least one of X1and X2is an N-oxide group. The compound exhibits an excellent phosphoinositol-3 kinase/protein kinase B (PI3K/Akt)-inhibiting effect, an excellent hypoxia-inducible factor (HIF)-inhibiting effect and an excellent antitumor effect. COPYRIGHT: (C)2011,JPO&INPIT