发明名称 |
NOVEL RETINAMIDE RETINOIC ACID METABOLISM BLOCKING AGENTS |
摘要 |
Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.
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申请公布号 |
US2011059974(A1) |
申请公布日期 |
2011.03.10 |
申请号 |
US20090991822 |
申请日期 |
2009.05.07 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
NJAR VINCENT C. O.;GEDIYA LALJI K.;KHANDELWAL AAKANKSHA |
分类号 |
A61K31/4164;A61K31/41;A61K31/4196;A61K31/52;A61K31/53;A61P35/00;C07D233/61;C07D403/12;C07D473/00;C07D473/38 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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