ANTI ErbB2 RNA APTAMER AND APPLICATIONS THEREFOR

摘要

The present invention relates to an anti ErbB2 RNA aptamer which has a high affinity for and binds specifically to the extracellular domain of ErbB2, and relates to applications for the aptamer as a composition for the treatment and diagnosis of relevant medical conditions which occur due to changes in ErbB2 expression or signal transmission in which ErbB2 is involved. The RNA aptamer of the present invention can be usefully applied as an in-vivo or ex-vivo tumour imaging means and an anti-tumour composition for cancers involving the over-expression of ErbB2.