发明名称 |
O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates |
摘要 |
<p>O 2 -Substituted 1-[(2-carboxylato)pyrrolidin-1-yl] diazeniumdiolates are stable in aqueous solution and, in many cases, they can be activated for NO release by enzymatic action. Furthermore, if an N-nitroso derivative is formed by net formal cleavage of the N-N double bond of the 1-[(2-carboxylato)pyrrolin-1-yl]diazen-1-ium-1,2-diolate, the N-nitroso compound is noncarcinogenic. Such compounds are believed to be particularly useful in the treatment of fulminant liver failure, malaria, respiratory problems, impotence, and a variety of cardiovascular/hematologic disorders.</p> |
申请公布号 |
EP2292630(A1) |
申请公布日期 |
2011.03.09 |
申请号 |
EP20100010885 |
申请日期 |
1997.09.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SAAVEDRA, JOSEPH E.;KEEFER, LARRY K. |
分类号 |
C07H19/06;A61K31/655;A61K31/7064;A61K31/726;A61K31/785;A61P9/00;A61P11/00;A61P15/10;A61P29/00;A61P31/00;A61P35/00;C07C291/08;C07D207/16;C07D213/64;C07D239/34;C07D295/28;C07H19/16 |
主分类号 |
C07H19/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|