发明名称 |
REMEDY FOR OVERACTIVE BLADDER COMPRISING ACETIC ACID ANILIDE DERIVATIVE AS THE ACTIVE INGREDIENT |
摘要 |
<p>(R)-2-(2-aminothiazol-4-yl)-4'-Ä2-Ä(2-hydroxy-2-phenylethyl)aminoÜethylÜacetic acid anilide or its salt shows a potent bladder relaxation effect in "isolated rat bladder smooth muscle relaxation test", dose-dependently lowers the contraction frequency of rhythmic bladder contractions in "rat rhythmic bladder contraction measurement test" and, moreover, prolongs the urination intervals in "urination functions measurement test on cyclophosphamide-induced overactive bladder model rat". Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.</p> |
申请公布号 |
EP1559427(B1) |
申请公布日期 |
2011.03.09 |
申请号 |
EP20030770134 |
申请日期 |
2003.11.04 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
TAKASU, TOSHIYUKI;SATO, SHUICHI;UKAI, MASASHI;MARUYAMA, TATSUYA |
分类号 |
A61K31/426;A61P13/00;A61P13/10;C07D277/40 |
主分类号 |
A61K31/426 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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