发明名称 |
Double-transfected cell line useful for the identification of transport inhibitors |
摘要 |
Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates. |
申请公布号 |
EP2292738(A1) |
申请公布日期 |
2011.03.09 |
申请号 |
EP20100011668 |
申请日期 |
2002.06.05 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES OEFFENTLICHEN RECHTS;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
CUI, YUNHAI;KOENIG, JOERG;KEPPLER, DIETRICH |
分类号 |
C12N5/10;C12N15/09;C12N5/071;C12Q1/02;G01N33/00;G01N33/50;G01N33/68 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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