| 发明名称 |
RETINAL PIGMENTED EPITHELIUM DERIVED NEUROTROPHIC FACTOR |
| 摘要 |
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor. The present invention also relates to a recombi-nant DNA molecule comprising a gene encoding a retinal pigmented epithelium derived neurotrophic factor having the DNA se-quence or the amino acid sequence in SEQ ID NO 1 and to an organism transformed with the recombinant DNA molecule. In addition, the present invention relates to a method of treating tumors, ocular diseases, nerve injuries, and conditions resulting from the activity of serine proteases, which comprises administering retinal epithelium derived neurotrophic factor.
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| 申请公布号 |
CA2137377(C) |
申请公布日期 |
2011.03.08 |
| 申请号 |
CA19932137377 |
申请日期 |
1993.06.04 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
JOHNSON, LINCOLN V.;TOMBRAN-TINK, JOYCE;CHADER, GERALD J.;STEELE, FINTAN R.;BECERRA, SOFIA PATRICIA |
| 分类号 |
A61K38/22;C12N15/18;A61K38/00;A61K38/18;A61K38/55;A61K38/57;A61P1/16;A61P3/08;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P25/00;A61P27/02;A61P27/14;A61P31/04;A61P33/00;A61P35/00;A61P37/08;A61P43/00;C07H21/04;C07K1/14;C07K1/18;C07K1/20;C07K14/475;C07K14/48;C07K14/52;C07K14/81;C12N1/21;C12N9/99;C12N15/09;C12N15/15;C12P21/02 |
主分类号 |
A61K38/22 |
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