NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUNDS AND THE MANUFACTURING PROCESS THEREOF

摘要

PURPOSE: A novel peptide deformylase inhibitor compound is provided to be used as a therapeutic agent for respiratory diseases and a therapeutic agent for respiratory diseases. CONSTITUTION: A novel peptide deformylase inhibitor compound is denoted by chemical formula I. The compound of chemical formula I and pharmaceutically acceptable salt thereof are prepared by reacting a compound of chemical formula III with a compound of chemical formula IVa or IVb or salt thereof. The reaction is performed under the presence of tetrahydrofuran, dichloromethane, N,N-dimethyl formaldehyde. An antibacterial composition contains therapeutically effective amount of novel peptide deformylase inhibitor compound or salt thereof and pharmaceutically acceptable carrier.