2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS

摘要

PURPOSE: An imidazole compound with substituted 2-pyridyl for treating ALK5 or ALK4 receptor-mediated diseases is provided. CONSTITUTION: An imidazole compound with substituted 2-pyridyl is denoted by chemical formula I. A pharmaceutical composition contains the compound of chemical formula I, pharmaceutically acceptable salt or hydrate thereof, and pharmaceutically acceptable diluents or carrier. The liver, kidney, or lung thrombosis is treated by administering effective amount of the compound of chemical formula I to a mammal, human.