Halo-5-alkyl-10-oxo-10,11-dihydrodibenz (b,f) azepines - useful as pharmaceutical intermediates, prepd by cyclisn of 2-methyl-2'-methoxy

摘要

Cpds. of formula (I): (where R1 = 1-5C alkyl, one X is Cl and the others are H) are prepd. by cyclisation. of a cpd. of formula (II): with lithium diethylamide in a mixt. of anhydrous benzene and P(NMe2)3 at ca -20 degrees C (I) are intermediates for pharmacologically active 10,11-dihydrodibenz b,f azepines esp. the corresp. 10-amino derivs.