发明名称 |
LIVE ATTENUATED SALMONELLA VACCINE |
摘要 |
The present invention is related to double and triple attenuated mutant strains of a bacterium infecting veterinary species such as Salmonella enterica and/or (a pathogenic) Escherichia coli. The mutants of the invention contain at least one first genetic modification and at least one second genetic modification, said first modification in one or more motility genes, and said second modification in one or more genes involved in the survival or the proliferation of the pathogen in the host. The present invention further relates to live attenuated vaccines based on such mutants for preventing amongst others Salmonellosis and/or an infection by an E. coli pathogen in a veterinary species.
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申请公布号 |
US2011052635(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
US20060293786 |
申请日期 |
2006.03.20 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL |
发明人 |
DE GREVE HENRI MARCEL JOZEF;ADRIAENSEN CONNIE THERESIA;HERNALSTEENS JEAN-PIERRE ERNEST CLEMENT |
分类号 |
A61K39/02;A61P31/04;C12N1/21;C12Q1/02 |
主分类号 |
A61K39/02 |
代理机构 |
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