发明名称 |
YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR |
摘要 |
Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis.
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申请公布号 |
US2011053857(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
US20090867724 |
申请日期 |
2009.02.13 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
LINDQUIST SUSAN L.;GITLER AARON D. |
分类号 |
A61K38/02;A61P25/28;C12N1/06;C12N1/19;C12N5/071;C12Q1/68 |
主分类号 |
A61K38/02 |
代理机构 |
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主权项 |
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地址 |
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