发明名称 |
METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME |
摘要 |
The present invention relates generally to a method of modulating tumor necrosis factor-mediated apoptosis and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated hepatocyte apoptosis by modulating an intracellular Bim and/or Bid-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by aberrant, unwanted or otherwise inappropriate tumor necrosis factor-mediated apoptosis. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject Bim and/or Bid-dependent signalling mechanism.
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申请公布号 |
US2011052603(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
US20070444579 |
申请日期 |
2007.10.05 |
申请人 |
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
BOUILLET PHILIPPE;STRASSER ANDREAS;GERONDAKIS STEVE;TAI FOOK LIN;KAUFMANN THOMAS;GUGASYAN RAFFI |
分类号 |
A61K39/395;A61K31/7088;A61K38/02;A61K38/45;A61K38/46;A61K38/48;A61P1/16;A61P31/12;A61P35/00;A61P37/06;C12N5/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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