发明名称 |
ANALYSIS OF MEMBRANE COMPONENT INTERACTIONS |
摘要 |
Devices and methods for detecting interaction between components associated with lipid membranes and analytes are described herein. In certain methods, a surface of a compartment of a device is coated with a material that attaches to lipid membrane from a sample. An analyte is introduced and interaction is detected, for example, by back scattering interferometry. In another method, a surface is passivated with a material that does not bind a lipid membrane. A sample is introduced that contains a membrane comprising a component for testing and an analyte. Interaction is detected. In a third method, a channel is filled with a first liquid that does not comprise a lipid membrane. A bolus of a second liquid that comprises a membrane comprising a component for testing and an analyte is introduced under laminar flow conditions so that a leading edge of the second liquid does not completely displace the first liquid in a sensing area that is interrogated by optical methods, for example, a laser. Interaction between the analyte and the component is detected. |
申请公布号 |
WO2010129027(A3) |
申请公布日期 |
2011.03.03 |
申请号 |
WO2010US01267 |
申请日期 |
2010.04.28 |
申请人 |
MOLECULAR SENSING, INC.;WEINBERGER, SCOT;DOTSON, STEPHEN;HARRIS, NATHAN |
发明人 |
WEINBERGER, SCOT;DOTSON, STEPHEN;HARRIS, NATHAN |
分类号 |
G01N35/08;G01N21/47;G01N33/48;G01N33/92 |
主分类号 |
G01N35/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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