PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OSTEOCHONDRAL DEFECTS
摘要
<p>The present invention provides compositions and methods for treating an osteochondral defect. In one embodiment, provided is a composition for treating an osteochondral defect comprising a biphasic biocompatible matrix and platelet derived growth factor (PDGF), wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase. In another embodiment, also provided is a method for treating an osteochondral defect in an individual comprising administering to the individual an effective amount of a composition comprising a biphasic biocompatible matrix and PDGF to at least one site of the osteochondral defect, wherein the biphasic biocompatible matrix comprises a scaffolding material and wherein the scaffolding material forms a porous structure comprising an osseous phase and a cartilage phase.</p>
申请公布号
WO2010102266(A8)
申请公布日期
2011.03.03
申请号
WO2010US26450
申请日期
2010.03.05
申请人
BIOMIMETIC THERAPEUTICS, INC.;KESTLER, HANS, K.;NICKOLS, JOSHUA;WISNER-LYNCH, LESLIE, A.;LIU, YANCHUN;RODEN, COLLEEN, M.
发明人
KESTLER, HANS, K.;NICKOLS, JOSHUA;WISNER-LYNCH, LESLIE, A.;LIU, YANCHUN;RODEN, COLLEEN, M.