发明名称 |
COMPOSITIONS AND METHODS OF USE OF IMMUNOTOXINS COMPRISING RANPIRNASE (RAP) SHOW POTENT CYTOTOXIC ACTIVITY |
摘要 |
The present invention concerns methods and compositions for forming immunotoxin complexes having a high efficacy and low systemic toxicity. In preferred embodiments, the toxin moiety is a ranpirnase (Rap), such as Rap(Q). In more preferred embodiments, the immunotoxin is made using dock-and-lock (DNL) technology. The immunotoxin exhibits improved pharmacokinetics, with a longer serum half-life and significantly greater efficacy compared to toxin alone, antibody alone, unconjugated toxin plus antibody or even other types of toxin-antibody constructs. In a most preferred embodiment the construct comprises an anti-Trop-2 antibody conjugated to Rap, although other combinations of antibodies, antibody fragments and toxins may be used to form the subject immunotoxins. The immunotoxins are of use to treat a variety of diseases, such as cancer, autoimmune disease or immune dysfunction.
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申请公布号 |
CA2770351(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
CA20102770351 |
申请日期 |
2010.08.30 |
申请人 |
IBC PHARMACEUTICALS, INC.;IMMUNOMEDICS, INC. |
发明人 |
CHANG, CHIEN-HSING;GOLDENBERG, DAVID M.;ROSSI, EDMUND A. |
分类号 |
C07K19/00;A61K47/48;C07K16/00;C07K16/28;C12N9/12;C12N9/22 |
主分类号 |
C07K19/00 |
代理机构 |
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