发明名称 |
METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRANSPLANT REJECTION |
摘要 |
Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. ThI, ThI 7 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation. |
申请公布号 |
WO2011026132(A2) |
申请公布日期 |
2011.03.03 |
申请号 |
WO2010US47384 |
申请日期 |
2010.08.31 |
申请人 |
1/3ACAMPLIMMUNE, INC.;LANGERMANN, SOLOMON;LIU, LINDA |
发明人 |
LANGERMANN, SOLOMON;LIU, LINDA |
分类号 |
C07K14/705;A61K38/17;A61K47/48;C07K16/28;G01N33/50;G01N33/564;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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