发明名称 |
DIAGNOSIS MARKER, DIAGNOSIS METHOD AND THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS, AND ANIMAL MODEL AND CELL MODEL DEVELOPING AMYOTROPHIC LATERAL SCLEROSIS |
摘要 |
Provided are a diagnosis marker, a diagnosis method, and a therapeutic agent suitable for diagnosing and treating amyotrophic lateral sclerosis (ALS). Also provided are an animal model and a cell model suitable for developing a therapeutic agent and a treatment method for ALS. The diagnosis method for ALS includes: an isolation step in which a nucleic acid is isolated from a specimen taken from a subject; a detection step in which bases expressed in a human chromosome 10 optineurin (OPTN) gene region are detected from the isolated nucleic acid; and a determination step in which it is determined whether or not the detected bases are mutated. |
申请公布号 |
WO2011024822(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
WO2010JP64313 |
申请日期 |
2010.08.24 |
申请人 |
HIROSHIMA UNIVERSITY;KAWAKAMI HIDESHI;MARUYAMA HIROFUMI;MORINO HIROYUKI |
发明人 |
KAWAKAMI HIDESHI;MARUYAMA HIROFUMI;MORINO HIROYUKI |
分类号 |
C12N15/09;A01K67/027;A61K45/00;A61P21/00;A61P25/00;A61P43/00;C12N5/10;C12N15/01;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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