发明名称 |
METHOD FOR PREPARING PRASUGREL |
摘要 |
<p>A method for preparing prasugrel is disclosed, wherein o-fluorobenzyl cyclopropyl ketone is converted toa-cyclopropylcarbonyl-2-fluorobenzyl halide (compound 2) using dibromohydantoin as halogenation agent and acetic acid as dissolvent, and then applying concerted catalysis method with phase transfer catalysts and inorganic salts to produce 2-oxo-4,5,6,7- tetrahydrothiopheno[3,2-c]pyridine tosylate (compound 4) in high yield, which is then subjected to condensation and acylation to obtain prasugrel as a gum. A purified method of prasugrel is also disclosed, wherein crystallization is performed using alcohols as crystallization solvents to obtain prasugrel with high purity.</p> |
申请公布号 |
WO2011023027(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
WO2010CN74310 |
申请日期 |
2010.06.23 |
申请人 |
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.;LIU, CHUANGWEI;LU, QIFENG;CHEN, CHANGHUI |
发明人 |
LIU, CHUANGWEI;LU, QIFENG;CHEN, CHANGHUI |
分类号 |
C07D495/04 |
主分类号 |
C07D495/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|