发明名称 |
PROCESS FOR THE PREPARATION OF (1S,4R)-2-OXA-3-AZABICYCLO[2,2.1]HEPT-5-ENES |
摘要 |
<p>Enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-ß-D-ribofuranosyl halides of formula wherein X is a halogen atom selected from fluorine, chlorine, bromine and iodine, PG2 is a hydroxyl-protective group and PG3 is a 1,2-diol-protective group.</p> |
申请公布号 |
WO2011023374(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
WO2010EP05199 |
申请日期 |
2010.08.25 |
申请人 |
LONZA LTD;FRANZEN, MANUELA;NOTI, CHRISTIAN |
发明人 |
FRANZEN, MANUELA;NOTI, CHRISTIAN |
分类号 |
C07D265/34;C07H5/00 |
主分类号 |
C07D265/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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