发明名称 NEW METHODS FOR THE PREPARATION OF TAXANES USING CHIRAL AUXILIARIES
摘要 A stereoselective synthesis of novel &bgr;-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new &bgr;-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The &bgr;-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane.
申请公布号 US2011054191(A1) 申请公布日期 2011.03.03
申请号 US20100939230 申请日期 2010.11.04
申请人 ACCORD HEALTHCARE LTD. 发明人 LOURDUSAMY METTILDA;CARON GAETAN
分类号 C07F7/18;C07D305/14;C07D407/14 主分类号 C07F7/18
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