摘要 |
A stereoselective synthesis of novel &bgr;-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new &bgr;-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The &bgr;-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane.
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