| 摘要 |
The present inventor employed surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to analyze distinctive serum proteomic patterns of hemodialysis patients. The present inventor found three peptides at 2,192, 2,789, and 2,851 m/z that showed a significant correlation with the levels of serum ferritin. The molecular sizes of the 2,192 and 2,789 m/z matched well with the reported sizes of hepcidin-20 and -25, respectively, and the latter completely coincided with the size of synthetic hepcidin-25. It would be possible to diagnose abnormal iron metabolism by detecting bioactive forms of hepcidin in the serum.
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