发明名称 |
METHOD OF INHIBITION OF LEUKEMIC STEM CELLS |
摘要 |
A method for inhibition of leukemic stem cells expressing IL-3Rα; (CD 123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3Rα(CD123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.
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申请公布号 |
US2011052574(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
US20080745607 |
申请日期 |
2008.12.04 |
申请人 |
CSL LIMITED;UNIVERSITY HEALTH NETWORK |
发明人 |
DICK JOHN EDGAR;JIN LIQING;VAIRO GINO LUIGI;GEARING DAVID PAUL;BUSFIELD SAMANTHA JANE |
分类号 |
A61K39/395;A61P35/04;C07K16/28;C12N5/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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