| 摘要 |
<p>The present invention is to provide manufacturing intermediates which can be led to useful ±-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide amino alcohol compounds represented by the following formula:
wherein R 1 and R 2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R 3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R 6 -O- or R 7 -N(R 8 )-; where R 6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R 7 and R 8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R 4 and R 5 represent the same groups as R 7 and R 8 , respectively, and R 9 and R 5 optionally form a ring together; and X represents -O- or -N(R 9 )-, where R 9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R 4 or R 5 ,
and processes for preparing ±-keto amide compound using the same.</p> |
