发明名称 |
Regulators of the hedgehog pathway, compositions and uses related thereto |
摘要 |
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations. |
申请公布号 |
EP1728797(A3) |
申请公布日期 |
2011.03.02 |
申请号 |
EP20060011086 |
申请日期 |
2000.10.13 |
申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
BEACHY, PHILIP, A.;CHEN, JAMES, K.;TAIPALE, ANSSI JUSSI |
分类号 |
A61K31/58;C07J69/00;A61P1/02;A61P1/16;A61P1/18;A61P11/00;A61P15/16;A61P15/18;A61P17/00;A61P17/02;A61P17/04;A61P17/06;A61P17/08;A61P17/12;A61P17/14;A61P17/16;A61P19/02;A61P19/04;A61P19/08;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P27/00;A61P27/12;A61P35/00;A61P43/00 |
主分类号 |
A61K31/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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