IMPROVED IMAGING OF IMMUNOMAGNETICALLY ENRICHED RARE CELLS
摘要
<p>A method for removing excess unbound ferrofluid and imaging immunomagnetically enriched circulating tumor cells is provided. A vessels having a preformed grooves in the viewing surface is optimally designed for cell alignment and imaging. After separating the unbound particles by centrifugation, an externally-applied force is applied to transport magnetically responsive particle-CTC complex toward the transparent collection wall. The grooved inner surface of the viewing face of the chamber provide uniform distribution of the particles for easy imaging. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques as in quantitative analysis of CTC in disease.</p>
申请公布号
EP2288919(A2)
申请公布日期
2011.03.02
申请号
EP20090751377
申请日期
2009.05.19
申请人
VERIDEX, LLC
发明人
SCHOLTENS, TYCHO, M.;SCHREUDER, FREDERIK;GREVE, JAN;TIBBE, ARJAN;TERSTAPPEN, LEON, W., M., M.