摘要 |
PURPOSE: An oxazole-piperazine compound having a pharmaceutical activity with respect to T-type calcium channel is provided to ensure excellent activity as an antagonist of the channel and to prevent and treat cancer, epilepsy, heart diseases, and pain. CONSTITUTION: An oxazole-piperazine compounds is denoted by chemical formula 1. A pharmaceutical composition for treating epilepsy, cancer, hypertension, myocardial infarction, neuropathic pain, and acute and chronic pain contains the oxazole-piperazine compound of chemical formula 1. The compound of chemical formula 1 is prepared by reacting piperazine-amine compound of chemical formula 2 and oxazole aldehyde compound of chemical formula 3 by reductive amination. The reductive amination is performed under the presence of molecules of 4-8 meshes and NaBH(OAc)_3, NaBH_3CN, or NaBH_4.
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申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
PAE, AE NIM;CHOO, HYUN AH;CHO, YONG SEO;LEE, JIE EUN;KEUM, GYO CHANG;CHOI, KYUNG IL;KIM, DONG JIN;SHIN, HEE SUP;RHIM, HYE WHON;CHUNG, HYE JIN;SEO, SEON HEE;SONG, CHI MAN |