发明名称 |
Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
摘要 |
The present invention relates to water-soluble taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives, and in particular to paclitaxel and docetaxel, useful for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenoisis. The invention also relates to the process for preparing taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives by direct synthesis between molecules of hyaluronic acid and of taxane or by indirect synthesis by the introduction of a spacer between the hyaluronic acid or hyaluronic acid derivative and the taxane.
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申请公布号 |
US7897584(B2) |
申请公布日期 |
2011.03.01 |
申请号 |
US20050531853 |
申请日期 |
2005.04.18 |
申请人 |
FIDIA FARMACEUTICI S.P.A. |
发明人 |
DE LUCA GILDA;BETTOLO RINALDO MARINI;MIGNECO LUISA MARIA |
分类号 |
A61K31/728;A61K47/48;A61P35/00;C08B37/00;C08B37/08 |
主分类号 |
A61K31/728 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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