发明名称 |
Viral chemokine-antigen fusion proteins |
摘要 |
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
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申请公布号 |
US7897152(B2) |
申请公布日期 |
2011.03.01 |
申请号 |
US20030380927 |
申请日期 |
2003.03.17 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KWAK LARRY W.;BIRAGYN ARYA |
分类号 |
A61K39/12;A61K31/00;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61P31/12;A61P35/00;C07K14/03;C07K14/16;C07K14/47;C07K14/52;C07K16/00;C07K16/28;C08H1/00;C12N1/21 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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