发明名称 |
Method for producing yeast expressed HPV types 6 and 16 capsid proteins |
摘要 |
Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice. |
申请公布号 |
US7897155(B2) |
申请公布日期 |
2011.03.01 |
申请号 |
US20080316310 |
申请日期 |
2008.12.11 |
申请人 |
NOVARTIS VACCINES & DIAGNOSTICS, INC. |
发明人 |
BUONAMASSA DANIELA TORNESE;GREER CATHERINE E.;GALEOTTI CESIRA L.;BENSI GIULIANO;PETRACCA ROBERTO |
分类号 |
A61K39/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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