| 发明名称 |
THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BASED ON THE ROLE OF THE CXCR-4 GENE IN TUMORIGENESIS |
| 摘要 |
<p>The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.</p> |
| 申请公布号 |
CA2323525(C) |
申请公布日期 |
2011.03.01 |
| 申请号 |
CA19992323525 |
申请日期 |
1999.03.29 |
| 申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
MURPHY, GERALD P.;BOYNTON, ALTON L.;SEHGAL, ANIL |
| 分类号 |
C12Q1/68;G01N33/53;A61K31/711;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07H21/04;C07K14/715;C07K16/00;C07K16/24;C07K16/28;C07K16/32;C12N15/09;C12N15/11;C12N15/85 |
主分类号 |
C12Q1/68 |
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