COMPOSITIONS AND METHODS FOR CONTROLLING TISSUE FACTOR SIGNALING SPECIFICITY

摘要

Compositions and methods for treating a disease dependent upon tissue factor/factor VIIa signaling in a mammalian subject is provided. The methods comprise administering an inhibitor of tissue factor signaling to the mammalian subject. The inhibitor is effective in reducing the incidence of disease in the mammalian subject. Also provided are methods of screening for modulators of tissue factor/factor VIIa signaling.