| 发明名称 |
BIPHENYL AMIDELACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 |
| 摘要 |
The present invention discloses novel compounds of Formula I:possessing 11&bgr;-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11&bgr;-HSD type 1 activity. |
| 申请公布号 |
EA014718(B1) |
申请公布日期 |
2011.02.28 |
| 申请号 |
EA20080070462 |
申请日期 |
2007.04.19 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
AICHER THOMAS, DANIEL;CHEN ZHAOGEN;HINKLIN RONALD, JAY;HITE GARY, ALAN;KRASUTSKY ALEXEI, PAVLOVICH;LI RENHUA;MCCOWAN JEFFERSON, RAY;SAEED ASHRAF;SNYDER NANCY, JUNE;TOTH JAMES, LEE;WALLACE OWEN, BRENDAN;WINNEROSKI JUNIOR LEONARD, LARRY;XU YANPING;YORK JEREMY, SCHULENBURG |
| 分类号 |
C07D207/12;A61K31/4015;A61P3/10;C07D401/10;C07D401/12;C07D403/10;C07D413/10;C07D417/10;C07D417/14;C07D471/04;C07D487/04;C07D487/08;C07D491/08;C07D491/10;C07D498/04 |
主分类号 |
C07D207/12 |
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