发明名称 |
Faktor VII- eller VIIa-polypeptidvarianter |
摘要 |
The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside of the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma. |
申请公布号 |
DK1499719(T3) |
申请公布日期 |
2011.02.28 |
申请号 |
DK20030717173T |
申请日期 |
2003.04.29 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
HAANING, JESPER, MORTENSEN;ANDERSEN, KIM, VILBOUR |
分类号 |
C12N9/64;C12N15/09;A61K38/00;A61K38/36;A61K38/38;A61K38/43;A61P7/04;A61P17/02;C07K14/745;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/57 |
主分类号 |
C12N9/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|